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By Targets:	Apoptosis (1) DNA Stain (1) Fluorescent Dye (1) Macrophage migration inhibitory factor (MIF) (1) SARS-CoV (6) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110084

BTZO-1	Macrophage migration inhibitory factor (MIF) Apoptosis	Cardiovascular Disease
BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a K_d value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro ^[1].

HY-D0917

TO-PRO 1	DNA Stain	Cancer
TO-PRO 1 is a DNA binding fluorochrome, that atached to the surface of the Feraheme (FH) nanoparticle (NP), to obtain a fluorochrome-functionalized NP. TO-PRO 1 binds DNA through intercalation, and acts as a vital fluorochrome for necrotic cells ^[1].

HY-D0918

YO-PRO-1	Fluorescent Dye	Others
YO-PRO-1 (Oxazole yellow) is a carbocyanine monomer and DNA green fluorescent dye that is not permeable to normal animal cell membranes but is permeable to the cell membranes of apoptotic and necrotic cells. YO-PRO-1 is commonly used for the detection of apoptosis and necrosis. YO-PRO-1 has a high affinity for DNA and is essentially non-fluorescent when not bound to DNA. When apoptosis occurs, the permeability of the cell membrane changes. YO-PRO-1 can enter apoptotic cells and bind to DNA and emit bright green fluorescence. Therefore, YO-PRO-1 is often used together with propidium iodide (PI) to analyze and identify apoptotic and necrotic cells.

HY-RS11202

PROS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PROS1 Human Pre-designed siRNA Set A PROS1 Human Pre-designed siRNA Set A

HY-P4388

Z-Arg-Leu-Arg-Gly-Gly-AMC

SARS-CoV Infection

Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .
HY-136298A

X77

SARS-CoV Infection

X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

Z-Arg-Leu-Arg-Gly-Gly-AMC	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

X77	SARS-CoV	Infection
X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-154976

SARS-CoV-2-IN-50	SARS-CoV	Infection
SARS-CoV-2-IN-50 (Compound X77C) is a SARS-CoV-2 main protease (M ^Pro) inhibitor.. SARS-CoV-2-IN-50 has a high affinity to the catalytic site of M ^Pro .

HY-136298

(Rac)-X77	SARS-CoV	Infection
(Rac)-X77 is a racemate of X77. X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-149655

D1N8	SARS-CoV	Infection
D1N8 is a potent SARS-CoV-2 3CL ^pro inhibitor with an IC₅₀ and CC₅₀ values of 0.44 μM and >20 μM, respectively. D1N8 has the potential for the research of anti-SARS-CoV-2 agents targeting 3CL ^pro .

HY-157145

SARS-CoV-2-IN-69	SARS-CoV	Infection
SARS-CoV-2-IN-69 (Compound 7E) is a non-covalent SARS-CoV-2 inhibitor with an EC₅₀ value of 7.4 μM. SARS-CoV-2-IN-69 is a potent inhibitor of SARS-CoV-2 main protease (M ^pro) and a non-covalent inhibitor of papain (PL ^pro) .

Cat. No.	Product Name	Type

HY-D0917

TO-PRO 1	DNA Stain
TO-PRO 1 is a DNA binding fluorochrome, that atached to the surface of the Feraheme (FH) nanoparticle (NP), to obtain a fluorochrome-functionalized NP. TO-PRO 1 binds DNA through intercalation, and acts as a vital fluorochrome for necrotic cells ^[1].

HY-D0918

YO-PRO-1	Fluorescent Dyes/Probes
YO-PRO-1 (Oxazole yellow) is a carbocyanine monomer and DNA green fluorescent dye that is not permeable to normal animal cell membranes but is permeable to the cell membranes of apoptotic and necrotic cells. YO-PRO-1 is commonly used for the detection of apoptosis and necrosis. YO-PRO-1 has a high affinity for DNA and is essentially non-fluorescent when not bound to DNA. When apoptosis occurs, the permeability of the cell membrane changes. YO-PRO-1 can enter apoptotic cells and bind to DNA and emit bright green fluorescence. Therefore, YO-PRO-1 is often used together with propidium iodide (PI) to analyze and identify apoptotic and necrotic cells.

YO-PRO-1

Fluorescent Dyes/Probes

YO-PRO-1 (Oxazole yellow) is a carbocyanine monomer and DNA green fluorescent dye that is not permeable to normal animal cell membranes but is permeable to the cell membranes of apoptotic and necrotic cells. YO-PRO-1 is commonly used for the detection of apoptosis and necrosis. YO-PRO-1 has a high affinity for DNA and is essentially non-fluorescent when not bound to DNA. When apoptosis occurs, the permeability of the cell membrane changes. YO-PRO-1 can enter apoptotic cells and bind to DNA and emit bright green fluorescence. Therefore, YO-PRO-1 is often used together with propidium iodide (PI) to analyze and identify apoptotic and necrotic cells.

Cat. No.	Product Name	Target	Research Area

HY-P4388

Z-Arg-Leu-Arg-Gly-Gly-AMC

SARS-CoV Infection

Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

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